Combinatorial Library Screening with Liposomes for Discovery of Membrane Active Peptides
نویسندگان
چکیده
منابع مشابه
Discovery of a Direct Ras Inhibitor by Screening a Combinatorial Library of Cell-Permeable Bicyclic Peptides
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It is estimated that membrane proteins comprise as much as 30% of most genomes. Yet our knowledge of membrane-protein folding is still in its infancy. Consequently, there is a great need for developing approaches that can further advance our understanding of how peptides and proteins interact with membranes and thereby attain their folded structure. An approach that we have been exploring invol...
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Microfluidic droplet-based screening of DNA-encoded one-bead-one-compound combinatorial libraries is a miniaturized, potentially widely distributable approach to small molecule discovery. In these screens, a microfluidic circuit distributes library beads into droplets of activity assay reagent, photochemically cleaves the compound from the bead, then incubates and sorts the droplets based on as...
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ژورنال
عنوان ژورنال: ACS Combinatorial Science
سال: 2017
ISSN: 2156-8952,2156-8944
DOI: 10.1021/acscombsci.6b00182